Pressure drop particle precipitation from a quasi-incompressible, ternary and liquid mixture

•Pressure drop can cause crystallization also in quasi-incompressible liquid mixtures.•Ibuprofen shows a pressure sensitive solubility in mixtures of water and acetone.•The solubility was quantified as a function of mixture composition and pressure.•Pressure decrease of saturated solutions results in supersaturated solution.•Solubility behaviour can be exploited for the precipitation of particles.