An activity-based fluorescent sensor for the detection of the phenol sulfotransferase SULT1A1 in living cells.

Regina A Baglia,Kira R Mills,Koushambi Mitra,Jasmine N Tutol,Darby Ball,Kierstin M Page,Jyothi Kallu,Sriharika Gottipolu,Sheena D'Arcy,Steven O Nielsen,Sheel C Dodani

RSC chemical biology（2021）

引用 3|浏览7

暂无评分

摘要

Human phenol sulfotransferases mediate the transfer of a sulfuryl moiety from the activated sulfate donor PAPS to hydroxy-containing substrates, altering substrate solubility and charge to affect phase II metabolism and cell signaling. Here, we present the development, computational modeling, in vitro enzymology, and biological application of STS-3, an activity-based fluorescent sensor for the SULT1A1 isoform.

查看译文

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要