Involvement of GRK2 in modulating nalfurafine-induced reduction of excessive alcohol drinking in mice

Neuroscience Letters（2021）

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摘要

•Excessive alcohol drinking increased grk2 expression in the NAc shell.•No effect of GRK2/3 inhibitor CMPD101 alone on alcohol drinking.•Nalfurafine decreased alcohol consumption.•CMPD101 enhanced the nalfurafine-induced reduction of drinking.

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关键词

CMPD101,Grk2,Nalfurafine,KOP-r,Excessive alcohol drinking,NAc shell,RNA-seq

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