A Thermally Activated Delayed Fluorescence Photosensitizer For Photodynamic Therapy Of Oral Squamous Cell Carcinoma Under Low Laser Intensity

JOURNAL OF MATERIALS CHEMISTRY B(2021)

引用 13|浏览13
暂无评分
摘要
In this report, a new thermally activated delayed fluorescence (TADF) molecule [2-(4-triphenylvinyl-phenyl)-anthraquinone (TPE-AQ)] was synthesized. This nanomaterial has satisfactory photostability. Through In vitro analysis, it was found that these TADF nanoparticles (NPs) targeted lysosomes in oral cancer cells. ROS were released under irradiation with a 450-nm laser, and the growth of xenograft tumors in mouse models was inhibited in vivo. More interestingly, radiation exposure caused little damage to normal tissues due to the low irradiation intensity (mA) used in the photodynamic therapy (PDT) treatment of oral cancer. Therefore, these TADF NPs provide new possibilities for the development of new PDT drugs for biomedical applications. In future work, possible functional modifications of TADF NPs for increased potency in clinical applications will be addressed.
更多
查看译文
关键词
delayed fluorescence photosensitizer,photodynamic therapy,delayed fluorescence,oral squamous cell carcinoma
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要