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IL-7 Immunotherapy in a Nonimmunocompromised Patient With Intractable Fungal Wound Sepsis.

Isaiah R Turnbull,Monty B Mazer,Mark H Hoofnagle,John P Kirby,Jennifer M Leonard,Carlos Mejia-Chew,Andrej Spec,Jane Blood,Sydney M Miles,Eric M Ransom,Robert F Potter,Joseph P Gaut,Kenneth E Remy,Richard S Hotchkiss

Open forum infectious diseases（2021）

Cited 9|Views8
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Abstract
A nonimmunocompromised patient developed life-threatening soft tissue infection with , , and that progressed despite maximum antifungal therapies and aggressive debridement. Interleukin-7 immunotherapy resulted in clinical improvement, fungal clearance, reversal of lymphopenia, and improved T-cell function. Immunoadjuvant therapies to boost host immunity may be efficacious in life-threatening fungal infections.
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Key words
Trichosporon,fungal infection,immunotherapy,interleukin-7,wound infection
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