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Characterisation Of Inverse Agonism Of The Orphan-G Protein-Coupled Receptor Gpr52 By Cannabinoid Ligands Cannabidiol And O-1918

Lisa A Stott,Cheryl A Brighton,Jason Brown,Richard Mould,Kirstie A Bennett,Robert Newman,Heather Currinn, Flavia Autore,Alicia P Higueruelo,Benjamin G Tehan,Cliona MacSweeney, Michael A O'Brien,Steve P Watson

HELIYON（2021）

Cited 2|Views28
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Abstract
The identification of cannabinoid ligands Cannabidiol and O-1918 as inverse agonists of the orphan receptor GPR52 is reported. Detailed characterisation of GPR52 pharmacology and modelling of the proposed receptor interaction is described. The identification of a novel and further CNS pharmacology for the polypharmacological agent and marketed drug Cannabidiol is noteworthy.
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Key words
GPR52, Inverse agonist, Cannabidiol, CBD, O-1918
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