Intrauterine growth restriction leads to a high-corticosterone producing offspring: An implication for pulmonary infection susceptibility
Life Sciences(2021)
Abstract
•Malnutrition in utero impairs fetal growth and leads to the diseases in adulthood.•IUGR impairs AA-pathway and production of crucial molecules to neutrophil recruitment.•IUGR jeopardizes TLR4 and NFKB activations and reduces lung inflammatory response.•IUGR compromises the HPA axis activation after the engagement of the immune cells.•IUGR hinder the natural response to bacterial infection, in adulthood.
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Key words
Intrauterine growth restriction,Acute lung inflammation,Low birth weight,Maternal undernutrition,Foetal programming
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