Single Cell Mass Spectrometry With a Robotic Micromanipulation System for Cell Metabolite Analysis

Anqi Chen, Mingyue Yan,Jiaxin Feng,Lei Bi,La Chen,Shundi Hu,Huanhuan Hong,Lulu Shi,Gangqiang Li,Baiye Jin,Xinrong Zhang,Luhong Wen

IEEE Transactions on Biomedical Engineering（2022）

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摘要

Objective: The increasing demand for unraveling cellular heterogeneity has boosted single cell metabolomics studies. However, current analytical methods are usually labor-intensive and hampered by lack of accuracy and efficiency. Methods: we developed a first-ever automated single cell mass spectrometry system (named SCMS) that facilitated the metabolic profiling ...

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关键词

Mass spectroscopy,Visual servoing,Micromanipulators,Metabolomics,Liquids,Technological innovation,Surface tension

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