Synergistic effects of a combined treatment of PI3K/mTOR dual inhibitor LY3023414 and carboplatin on human endometrial carcinoma

Nan Jia,Xiaoxia Che,Yahui Jiang,Menghan Zhu,Tong Yang,Weiwei Feng

Gynecologic Oncology（2021）

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摘要

•LY3023414 had synergistic inhibitory effects with carboplatin in vitro and in vivo for EC.•Enhanced carboplatin-induced DDR by LY3023414 may be the mechanism of synergistic effects.•Combined therapy had different anti-tumor effects in ECs with different mutational patterns of PI3K pathway.

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关键词

PI3K/mTOR dual inhibitor,LY3023414,Carboplatin,Endometrial cancer,Synergistic effects

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