Daphnetin inhibits spinal glial activation via Nrf2/HO-1/NF-κB signaling pathway and attenuates CFA-induced inflammatory pain
International Immunopharmacology（2021）
Abstract
•Administration with DAPH mitigates mechanical allodynia provoked by CFA.•DAPH restrains CFA-induced inflammation and spinal glial activation.•DAPH mediates negative regulation of spinal NF-κB pathway.•DAPH facilitates pain attenuation via the spinal activation of Nrf2/HO-1 pathway.
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Key words
Daphnetin,Inflammatory pain,Microglia,Astrocytes,Nrf2/HO-1/NF-κB signaling pathway,Pro-inflammatory cytokines
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