Copper-Catalyzed Three-Component Reactions Of Alpha-Ketoaldehyde, 1,3-Dicarbonyl Compound, And Organic Boronic Acid In Water: A Route To 1,4-Diketones

A novel three-component reaction of alpha-ketoaldehydes, 1,3-dicarbonyl compounds, and organic boronic acids catalyzed by CuO in water has been developed to give a wide range of products containing 1,3/1,4-diketones. The method has some advantages such as the use of readily available starting materials, wide substrate scopes, excellent yields, gram-scale synthesis, and mild reaction conditions.