Validation of ion mobility spectrometry - mass spectrometry as a screening tool to identify type II kinase inhibitors of FGFR1 kinase.

Helen S Beeston,Tobias Klein,Richard A Norman,Julie A Tucker,Malcolm Anderson,Alison E Ashcroft,Geoffrey A Holdgate

Rapid communications in mass spectrometry : RCM（2021）

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摘要

A robust ESI-IMS-MS method has been implemented to distinguish between the binding mode of type I and type II inhibitors by monitoring the conformational unfolding profile of FGFR1. This rapid method requires low sample concentrations and could be used as a high-throughput screening technique for the characterisation of novel kinase inhibitors.

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