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Polygenic risk of genes involved in the catecholamine and serotonin pathways for ADHD in children

Yanni Wang,Tingwei Wang,Yukai Du,Dan Hu,Yu Zhang,Honghui Li,Wenyan Pei

Neuroscience Letters（2021）

Cited 3|Views27
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Abstract
•Interaction of ADRA2A rs553668 and SLC6A4 rs6354 was significantly associated with the risk of ADHD.•The gene-gene interaction enhanced the power for ADHD susceptibility.•The unfavorable alleles of ADRA2A rs553668 G, DRD2 rs1124491 G and SLC6A4 rs6354 G showed a cumulative effect for ADHD.
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Key words
Attention deficit/ hyperactivity disorder,Gene-gene interaction,Polygenic risk,Child,Dopamine,Norepinephrine,Serotonin
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