Is it possible to repigment iatrogenic and traumatic hypochromic lesions? A case series using the MMP? drug delivery technique with 5-fluorouracil and bleomycin

Objectives We present the results of 11 patients with hypochromic lesions treated with antifibrotic agents delivered through the MMP (R) technique. Methods Eleven patients with hypochromic lesions because of external injuries were treated at a single clinic with 5-fluorouracil (5-FU) and/or bleomycin using the MMP (R) drug delivery technique. Treatment sessions were repeated at 30-day intervals until patient satisfaction. The primary outcome was repigmentation of the lesions, assessed independently by two dermatologists and by the patient. Results The MMP (R) technique injected 0.048 mg/cm(2) of 5-FU or 0.0028 U/cm(2) of bleomycin. The accumulated 5-FU and bleomycin density per patient ranged from 0.02 to 0.77 mg and 0.0022 to 0.2800 U/ml, respectively. Patients were treated with 1 to 6 MMP (R) sessions with 5-FU (3 patients), bleomycin (6 patients), or both drugs (2 patients). After the last session, all patients had a significant improvement (>75%) of the lesions compared to baseline. There were no procedure-related short- or long-term adverse effects in any of the participants up to their last follow-up visit. Conclusions The injection of antifibrotic agents using the MMP (R) technique was effective and safe in the treatment of hypochromic lesions. This can be a new therapeutic option for these lesions.