Simultaneous quantification of twenty-eight components of Shenfu Injection in rat plasma by UHPLC-QQQ MS and its application to a pharmacokinetic study

Bing-Qing Shen,Cheng Qu,Li Mi,Hui-Ying Wang,Hua Yang

Journal of Pharmaceutical and Biomedical Analysis（2021）

引用 6|浏览5

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摘要

•A rapid, sensitive and reliable UHPLC-QQQ MS method was developed and validated.•A pharmacokinetic study of twenty-eight components of Shenfu Injection in rats.•Systemic exposure levels of ginsenosides were greater than aconite alkaloids.

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关键词

TCMs,SFI,PPD,PPT,DDAs,MDAs,ADAs,IS,ESI,MRM,QC,RSD,RE,SD

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