Palladium-catalyzed cascade carbonylative annulation between alkene-tethered aryl iodides and carbon monoxide
CHEMICAL COMMUNICATIONS(2021)
摘要
Rapid construction of molecules bearing all-substituted quaternary stereocenters represents a highly significant but challenging task in organic synthesis. Herein, we report a novel palladium-catalyzed cascade between alkene-tethered aryl iodides and carbon monoxide, which has resulted in a practical and powerful method for the synthesis of complex polycyclic molecules containing aryl-substituted quaternary stereocenters. Mechanistic studies suggested that the reaction proceeded via a Heck-type carbonylative cyclization, followed by a ketene-involved Friedel-Crafts acylation.
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关键词
cascade carbonylative annulation,aryl iodides,palladium-catalyzed,alkene-tethered
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