The struggle against endometrial cancer: ten years of experience of a tertiary center

Objectives: We aimed to investigate the clinical and pathological factors of our patients who were diagnosed with en-dometrial cancer in terms of prognosis. With this study, we present our 10 years of surgical experience in endometrial carcinoma cases. Material and methods: Four hundred twelve patients with endometrial carcinoma who applied to our center between 2010-2019 and that we followed up were evaluated retrospectively. Results: Most of the tumors were low-grade endometrioid malignancies. Non-endometrioid types accounted for 12.1% of cases. Lymph node dissection was performed in 395 of 412 patients (95.9%). 66 (16.01%) of the 412 patients died during the follow-up period in the study sample. Higher OS and DFS rates were associated with endometrioid histological types, FIGO stage, absence of lymphovascular space invasion, lower grade and less than 50% myometrial invasion (p < 0.05). 5-year OS at stage 1, 2, 3, 4 was found as 88.9 +/- 2.2%, 65.5 +/- 10.8%, 49.4 +/- 0.79% and 23.7 +/- 0.97% respectively. 5-year DFS at stage 1, 2, 3, 4 was found as 84.1 +/- 2.6%, 65.5 +/- 10.8%, 47.7 +/- 0.78% and 23.7 +/- 0.97% respectively. In univariate analysis, Age, tumor histology, FIGO stage, histological grade, LVSI, positive peritoneal cytology, cervical involvement, myometrial invasion and not receiving adjuvant therapy were defined as prognostic factors. Conclusions: Age, grade, FIGO stage, myometrial invasion, histological type, LVSI involvement, cervical involvemet, posi-tive peritoneal cytology and not receiving adjuvant therapy are important prognostic factors for progression-free survival and overall survival in patients diagnosed with endometrial cancer.