Electrospun gold nanorods/graphene oxide loaded-core-shell nanofibers for local delivery of paclitaxel against lung cancer during photo-chemotherapy method

European Journal of Pharmaceutical Sciences(2021)

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摘要
•Photothermal therapy and chemotherapy have been simultaneous applied.•The dual pH/temperature responsive nanofibrous formulation was synthesized.•Poly (tetramethylene ether) glycol based polyurethane/chitosan nanofibers were fabricated.•Paclitaxel and graphene oxide/gold nanorods were simultaneously loaded into fibers.•Laser irradiation resulted in accelerating of paclitaxel release of from nanofibers.•Maximum cytotoxicity against A549 lung cancer was 85% using photo/chemotherapy.
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关键词
Gold nanorods/graphene oxide,Core-shell nanofibers,Chitosan,Lung cancer,Photothermal/chemotherapy
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