From Bench to Biomolecular Simulation: Phospholipid Modulation of Potassium Channels

Tanadet Pipatpolkai,Daniel Quetschlich,Phillip J. Stansfeld

Journal of Molecular Biology（2021）

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摘要

•Interactions of lipids with K+ channels.•Structural basis of PIP2 binding.•Experimental methods for quantifying PIP2-binding to K+ channels.•Molecular simulation methods for studying PIP2 binding.

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关键词

K+ channels,phospholipids,phosphatidylinositol-bisphosphate,protein-lipid interactions,molecular dynamics simulations,electrophysiology,flux assays,mass spectrometry,Super-resolution microscopy,X-ray crystallography,Cryo-EM microscopy

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