Impact Of Tisagenlecleucel Chimeric Antigen Receptor (Car)-T Cell Therapy Product Attributes On Clinical Outcomes In Adults With Relapsed Or Refractory Diffuse Large B-Cell Lymphoma (R/R Dlbcl)

BLOOD(2019)

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摘要
Background: In the phase 2 JULIET trial, tisagenlecleucel, an anti-CD19 CAR-T cell therapy, demonstrated durable responses and manageable safety in adult patients (pts) with r/r DLBCL. Here, we examine the impact of key product cellular attributes of tisagenlecleucel on clinical outcomes.
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关键词
Refractory Diffuse Large B-Cell Lymphoma,Diffuse large B-cell lymphoma,Chimeric antigen receptor,Cell therapy,Cytokine release syndrome,Immunophenotyping,Human leukocyte antigen,Cancer research,Flow cytometry
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