Simultaneous quantification of vincristine and its major M1 metabolite from dried blood spot samples of Kenyan pediatric cancer patients by UPLC-MS/MS

Lorita Agu,Jodi L Skiles,Andrea R Masters,Jamie L Renbarger,Diana S-L Chow

Journal of Pharmaceutical and Biomedical Analysis（2021）

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摘要

•Incorporation of formic acid enhanced M1 extraction from human dried blood spots.•Quantification of vincristine and M1 from human dried blood spots.•UPLC-MS/MS method to monitor vincristine and M1 in Kenyan pediatric cancer patients.

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关键词

Vincristine,M1 metabolite,Dried blood spots,UPLC-MS/MS,Kenyan pediatric patients,Cancer

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