Chronic early-life social isolation affects NMDA and TrkB receptor expression in a sex-specific manner

Nyasha Gondora,Christopher B. Pople, Gorvie Tandon,Morgan Robinson, Eden Solomon,Michael A. Beazely,John G. Mielke

Neuroscience Letters（2021）

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摘要

•Chronic early-life social isolation (CELSI) uniquely alters plasticity proteins.•CELSI increases TrkB expression in the HP and PFC of male, but not female, rats.•CELSI increases GluN2B expression in the HP and PFC of male, but not female, rats.

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关键词

TrkB,GluN2B,Stress,Early-life stress,Isolation rearing

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