Long-term, multidomain analyses to identify the breed and allelic effects in MSTN -edited pigs to overcome lameness and sustainably improve nutritional meat production
Science China Life Sciences(2021)
摘要
Beef and mutton production has been aided by breeding to integrate allelic diversity for myostatin ( MSTN ), but a lack of diversity in the MSTN germplasm has limited similar advances in pig farming. Moreover, insurmountable challenges with congenital lameness and a dearth of data about the impacts of feed conversion, reproduction, and meat quality in MSTN -edited pigs have also currently blocked progress. Here, in a largest-to-date evaluation of multiple MSTN -edited pig populations, we demonstrated a practical alternative edit-site-based solution that overcomes the major production obstacle of hindlimb weakness. We also provide long-term and multidomain datasets for multiple breeds that illustrate how MSTN -editing can sustainably increase the yields of breed-specific lean meat and the levels of desirable lipids without deleteriously affecting feed-conversion rates or litter size. Apart from establishing a new benchmark for the data scale and quality of genome-edited animal production, our study specifically illustrates how gene-editing site selection profoundly impacts the phenotypic outcomes in diverse genetic backgrounds.
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关键词
MSTN -edited pigs
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