Pan-methylarginine antibody generation using PEG linked GAR motifs as antigens

Yalong Wang,Maria D Person,Mark T Bedford

Methods（2022）

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摘要

•Using PEG linked antigens to develop pan-methylarginine antibodies.•Successfully developed MMA, SDMA and ADMA antibody sets.•SmD1 is a protein that substrate switches in the presence of PRMT5 inhibition.•These antibodies can be used to evaluate target engagement of PRMT inhibitors.

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关键词

Arginine methylation,MMA,ADMA,SDMA,SmD1

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