Kilohertz full-frame two-photon imaging of cortical hemodynamics in vivo
High-Speed Biomedical Imaging and Spectroscopy VI（2021）
Abstract
Uncovering the structure and function of cortical vascular network down to the level of capillaries can provide useful insights on brain physiology and pathology. Ideally, the probing method should allow concurrent observation of vascular morphology and hemodynamics, with sufficient spatiotemporal resolution to resolve individual capillaries and track blood cell motion in the scattering mammalian brain. By employing an all-optical scanning two-photon fluorescence microscope, we realized kilohertz full-frame recording of cortical blood vessels beyond 700 µm deep in the mouse brain and measured blood flow speeds up to 15 mm/s
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Key words
Hemodynamics,Blood flow,Two-photon excitation microscopy,Fluorescence microscope,Biomedical engineering,In vivo,Materials science,Spatiotemporal resolution,Vascular morphology,Vascular network
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