Rational design of AIE-based fluorescent probes for hypochlorite detection in real water samples and live cell imaging.
Journal of hazardous materials(2021)
Abstract
As one kind of important disinfectant and reactive oxygen species (ROS), hypochlorite (ClO-), plays vital roles in both water treatment and cell homeostasis. In this work, by decorating a series of groups with different electron donating and withdrawing properties on tetraphenylethene (TPE), four aggregation-induced emission (AIE)-based fluorescent probes containing C˭C double bonds as the potential reaction sites named Probe A, B, C and D were constructed, and their sensing performance for ClO- was systematically studied. The results showed that the substituents can not only effectively tune the photophysical properties of the probes, but also make a significant impact on their sensing performance for ClO-. Combined with the theoretical calculation results, it can be inferred that the reactivity of the probes for ClO- can be greatly enhanced with the increase of electron cloud density on the C˭C double bonds by the introduction of strong electron-donating group (EDG) and electron-withdrawing group (EWG) adjacent to the double bonds. Finally, the best performing Probe D was selected and then successfully applied to ClO- detection in real water samples and live cell imaging.
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