Two new cytotoxic cycloartane triterpenoids fromAphanamixis polystachya (Wall.) R. N. Parker

Two new cycloartane triterpenoids, (24 R)-cycloartane-3β,24,25,30-tetrol (1) and (24 R)-24,25,30-trihydroxy-9,19-cycloartane-3-one (2), along with three known compounds (3-5) were isolated from leaves and twigs ofAphanamixis polystachya. The new compounds were elucidated based on comprehensive spectroscopic analysis, including 1 D, 2 D NMR and HREIMS. The in vitro cytotoxic activities evaluation of five human cancer cell lines revealed that compound1 exhibited cytotoxic activity on all of tested human cancer cell lines, while compound2 only had specific activity on SMMC-7721 cell line.