Improved efficacy/safety profile of factor XIa inhibitor BMS-724296 versus factor Xa inhibitor apixaban and thrombin inhibitor dabigatran in cynomolgus monkeys.
Research and practice in thrombosis and haemostasis（2021）
摘要
BMS-724296 produced similar antithrombotic efficacy as apixaban and dabigatran but with no increase in KBT in NHPs. These findings suggest that FXIa inhibitors may provide safe and effective antithrombotic therapy.
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关键词
anticoagulant,antithrombotic agent,apixaban,blood coagulation,dabigatran,factor XIa inhibitor,hemostasis,thrombosis
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