The protective effect of olanzapine on ketamine induced cognitive deficit and increased NR1 expression in rat model of schizophrenia.

Ghada S Mahmoud,Ghada Hosny,Sally A Sayed

International journal of physiology, pathophysiology and pharmacology（2021）

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摘要

Current study demonstrated the efficacy of OLZ to reverse KET-induced cognitive deficits in ASST with neither reduction in NR1 expression in PFC nor metabolic malfunction in the sub-chronic study. It also showed the protective effect of OLZ on KET induced neuronal degeneration and necrosis. We suggest that chronic OLZ treatment-induced-metabolic malfunction might be the cause of time-dependent cognitive deterioration.

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关键词

N methyl-D-aspartate receptors (NMDARs),Schizophrenia,attention set shifting task (ASST),ketamine (KET),olanzapine (OLZ)

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