The protective effect of olanzapine on ketamine induced cognitive deficit and increased NR1 expression in rat model of schizophrenia.
International journal of physiology, pathophysiology and pharmacology(2021)
摘要
Current study demonstrated the efficacy of OLZ to reverse KET-induced cognitive deficits in ASST with neither reduction in NR1 expression in PFC nor metabolic malfunction in the sub-chronic study. It also showed the protective effect of OLZ on KET induced neuronal degeneration and necrosis. We suggest that chronic OLZ treatment-induced-metabolic malfunction might be the cause of time-dependent cognitive deterioration.
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关键词
N methyl-D-aspartate receptors (NMDARs),Schizophrenia,attention set shifting task (ASST),ketamine (KET),olanzapine (OLZ)
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