Cryo-EM structure of the cetacean morbillivirus nucleoprotein-RNA complex

Luca Zinzula,Florian Beck,Sven Klumpe,Stefan Bohn,Günter Pfeifer,Daniel Bollschweiler,István Nagy,Jürgen M Plitzko,Wolfgang Baumeister

Journal of Structural Biology（2021）

引用 6|浏览11

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摘要

•Cetacean morbillivirus (CeMV) nucleocapsid (N)-like particle reconstituted in vitro.•Cryo-EM 4 Å resolution structure of helical CeMV ribonucleoprotein complex solved.•Genome packaging by CeMV N through ssRNA binding and homo-oligomerization described.•Framework to study functional properties of N variants among CeMV strains provided.

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关键词

Cetacean morbillivirus,Nucleocapsid,RNA virus replication,Cryo-electron microscopy,Helical reconstruction

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