HCV resistance-associated substitutions following direct-acting antiviral therapy failure – Real-life data from Poland

Miłosz Parczewski,Ewa Janczewska,Arkadiusz Pisula,Dorota Dybowska,Władysław Łojewski,Adam Witor,Marta Wawrzynowicz-Syczewska,Łukasz Socha,Rafał Krygier,Brygida Knysz,Joanna Musialik,Anna Urbańska,Kaja Scheibe,Jerzy Jaroszewicz

Infection, Genetics and Evolution（2021）

Cited 2|Views7

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Abstract

•Resistance associated mutation to NS5A and NS3 agents are common among HCV directly acting antiviral failing patients.•Glecaprevir/pibrentasvir retained activity in majority of DAA failing patients.•The frequency of NS3, but not NS5A resistance substitutions decreases over time indicating reversal to drug susceptibility.

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Key words

HCV resistance,Resistance-associated substitutions,Directly acting antivirals

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