Polyglutamylase activity of tubulin tyrosine ligase-like 4 is negatively regulated by the never in mitosis gene A family kinase never in mitosis gene A -related kinase 5.
World journal of biological chemistry（2021）
摘要
Our results demonstrate, for the first time, the regulation of TTLL activity through phosphorylation, pointing to NEK5 as a potential effector kinase. We also suggest a general control of tubulin polyglutamylation through NEK family members in human cells.
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关键词
Kinase,Microtubules,Never in mitosis gene A-related kinase 5,Polyglutamylation,Post translational regulation,Tubulin tyrosine ligase-like 4
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