Augmentation in NF-κB, NRF2 and FAAH Gene Expression in Bipolar Depression
BIOLOGICAL PSYCHIATRY(2021)
Abstract
Bipolar Disorder (BD) is associated with increased inflammatory and oxidative stress markers. Nuclear factor erythroid 2-related factor-2 (NRF2) is a transcription factor implicated in the antioxidant response while the nuclear factor kappa B (NF-κB) participates in the transcription of genes related to the inflammatory response. The enzymes monoacylglycerol lipase (MGLL) and fatty-acid-amide hydrolase (FAAH) are endocannabinoid-degrading enzymes whose inhibition leads to a reduction in neuroinflammation. If implicated in BD, these factors might become novel treatment targets.
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Key words
Bipolar Depression,Inflammation,NFkB,NRF2,FAAH
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