Ly6c hi Infiltrating Macrophages Promote Cyst Progression in Injured Conditional Ift88 Mice.

Ernald Jules G Aloria,Cheng J Song,Zhang Li,Mandy J Croyle,Michal Mrug,Kurt A Zimmerman,Bradley K Yoder

Kidney360（2021）

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摘要

Key Points Ly6c(hi) infiltrating macrophage numbers are increased in injured, conditional Ift88 mice, compared with controls. Loss of Ly6c(hi) infiltrating macrophages slows injury-accelerated cystic disease. Ly6c(hi) infiltrating macrophages drive cystic disease in non-Pkd1-deficient cystic models.

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关键词

cystic kidney disease, basic science, cilia, ciliopathy, infiltrating macrophages, polycystic kidney disease, renal cysts

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