Enzymes inhibition profiles and antibacterial activities of benzylidenemalononitrile derivatives

•Benzylidenemalononitrile derivatives were investigated as being hCA-I, hCA-II, and hAChE inhibitors.•Compound 5 was the most effective inhibitor for both hCA isozymes.•Compound 3 was the most effective inhibitor for hAChE with Ki value of 0.058 ± 0.014 µM.•Molecular docking studies were performed to get insight into the inhibition mechanism.•Molecule 5 and 7 are the most effective compound against K. pneumonia, and S. aureus respectively.