The glucuronide metabolites of kaempferol and quercetin, targeting to the AKT PH domain, activate AKT/GSK3β signaling pathway and improve glucose metabolism

Ge Fang,Chuanjing Cheng,Manqian Zhang,Xiaoyao Ma,Shengnan Yang,Xiaotao Hou,Jiagang Deng,Yuanyuan Hou,Gang Bai

Journal of Functional Foods（2021）

引用 6|浏览10

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摘要

•Glucuronide metabolites are the major metabolites of kaempferol and quercetin.•The glucuronide metabolites target the AKT PH domain to activate AKT.•The glucuronide metabolites improve glucose metabolism.

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关键词

Kaempferol-3-glucuronide,Quercetin-3-glucuronide,Glucose metabolism,AKT,PH domain

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