The Koebner phenomenon may contribute to the development of calciphylaxis: A case series

Calciphylaxis is characterized by calcific occlusion of vessels and subsequent tissue ischemia due to thrombosis.1,2 The precise pathogenetic mechanism behind calciphylaxis remains unclear. In the original experiment by Hans Selye and colleagues,3-7 soft-tissue calcification was induced in rats by applying a sensitizing agent, followed by a “challenger” agent after a specific time period. Trauma may represent one of these “challenger” agents, serving as an inducer of endothelial dysfunction and subsequent thrombosis, leading from tissue calcification to calciphylaxis.