D-cycloserine normalizes long-term motor plasticity after transcranial magnetic intermittent theta-burst stimulation in major depressive disorder

Jaeden Cole,Ben Selby,Zahinoor Ismail,Alexander McGirr

Clinical Neurophysiology（2021）

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摘要

•Intermittent theta burst stimulation (iTBS) leads to sustained decrease in MEP recruitment curve in healthy controls, but increase in major depressive disorder (MDD).•D-cycloserine normalizes iTBS induced MEP recruitment curve changes in MDD.•2D-cycloserine stabilizes iTBS induced MEP recruitment curve changes in both healthy controls and MDD.

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关键词

Major depressive disorder,MDD,Intermittent theta burst stimulation,Motor cortex,D-Cycloserine,NMDA receptor

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