POS-395 P66SHC-MEDIATED H2O2 PRODUCTION IMPAIRS NEPHROGENESIS CAUSING REDUCTION OF NUMBER OF GLOMERULI
Kidney International Reports(2021)
Abstract
Adaptor protein p66Shc, one of three Shc1 gene products, contributes to the pathogenesis of oxidative stress-related diseases and is known to regulate the sensitivity to oxidative stress. The objective of this study was to test the hypothesis that abnormal p66Shc-mediated reactive oxygen species (ROS) production could be critically involved in the development of nephrons during nephrogenesis. p66Shc ability to promote oxidative stress-related diseases requires phosphorylation of serine 36 residue (Ser-36), which causes conformation change and consequent translocation of p66Shc to the mitochondria where it increases the production of ROS.
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Key words
h2o2 production impairs,glomeruli,shc-mediated
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