Clinical Problem Solving: An Older Woman With Weakness from Head to Toe

David A. Hartmann,Meredith Bock,Vanja Douglas,Josiah Gerdts,Biswarathan Ramani,Maulik Shah

NEUROHOSPITALIST（2022）

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摘要

A 67-year-old woman was admitted to our hospital for progressive weakness, dysphagia, muscle pain, and weight loss. Here we detail the clinical problem solving involved in diagnosing and treating her immune-mediated necrotizing myopathy caused by anti-HMGCoA reductase autoantibodies. Interestingly, this diagnosis coincided with discovery of a gastrointestinal stromal tumor (GIST) and positivity for anti-nuclear matrix protein (anti-NXP2), another myositis specific autoantibody.

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关键词

autoimmune diseases of the nervous system, neuromuscular disease, clinical specialty, myositis, neuromuscular diseases, muscular diseases, neuromuscular diseases, education, techniques

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