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Importance Of Local Glycan Heterogeneity For In Vivo Cancer Targeting

Ivan Smirnov,Igor Nasibullin,Almira Kurbangalieva,Katsunori Tanaka

TETRAHEDRON LETTERS（2021）

Cited 3|Views1
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Abstract
The preparation of heterogeneous glycoclusters on human serum albumin, containing two structurally non-identical N-glycans, is reported. In agreement with the cell-based interaction data, the trivial structural difference in local glycan heterogeneity can affect the in vivo distribution and cancer accumulation. (C) 2021 Elsevier Ltd. All rights reserved.
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N-glycan, Targeting, RIKEN click reaction, Albumin, 6 pi-Azaelectrocyclization
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