Analytical Performance Of The Xpert Mtb/Xdr (R) Assay For Tuberculosis And Expanded Resistance Detection

Sophia B Georghiou,Adam Penn-Nicholson,Margaretha de Vos,Aurélien Macé,Melanie W Syrmis, Kevin Jacob, Alyanna Mape,Heta Parmar,Yuan Cao,Chris Coulter,Morten Ruhwald,Sushil K Pandey,Samuel G Schumacher,Claudia M Denkinger

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE（2021）

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摘要

In a manufacturer-independent laboratory validation study, the Xpert MTB/XDR (R) assay demonstrated equivalent limit of detection to Xpert MTB/RIF (R), detected 100% of tested resistance mutations and showed some utility for resistance detection in strain mixtures. The Xpert MTB/XDR assay is a reliable, sensitive assay for tuberculosis and expanded resistance detection. (C) 2021 The Authors. Published by Elsevier Inc.

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关键词

Drug-resistance tuberculosis, molecular diagnostics, drug susceptibility testing

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