POS-792 OMEGA-3 ATTENUATES UREMIA-INDUCED BRAIN DAMAGE IN MICE

E.J. Kim, J.J. Kim,J.Y. Jeong, Y.R. Ham, K.R. Na,K.W. Lee, E. Lee, J.I. Lee,Y.K. Chang,D.E. Choi, H.R. Kim,J.W. Jeon

Kidney International Reports（2021）

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Abstract

Although the cause of central nervous system (CNS) disorder in patients with CKD has not been completely identified yet, recent papers have attributed accumulated uremic toxin to be its main cause. Additionally, omega-3 polyunsaturated fatty acid (ω3-PUFA) is abundant in the nervous system and plays an important role in maintaining normal nerve function. The objective of this study is to identify brain damage caused by uremic toxicity and determine the protective effects of ω-3 PUFA against uremic toxin.

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Key words

mice,uremia-induced

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