Engineering of Saccharomyces pastorianus old yellow enzyme 1 for the synthesis of pharmacologically active (S)-profen derivatives

Guigao Liu,Shang Li,Qinghua Shi,Hengyu Li,Jiyang Guo,Jingping Ouyang,Xian Jia,Lihan Zhang,Song You,Bin Qin

Molecular Catalysis（2021）

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摘要

•Identification of the key residues for the stereo-control of ene reductase OYE1.•Engineering of OYE1 for the synthesis of active (S)-profen derivatives.•Up to >99 % stereoselectivity was observed for the asymmetric reduction.

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关键词

Ene reductases,Profen,OYE1,Biocatalysis,Protein engineering

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