Artificial Intelligence Models Reveal Sex-Specific Gene Expression in Aortic Valve Calcification

•Differences in the clinical presentation and physiology of aortic stenosis in men and women complicate the management of the condition.•By combining traditional inferential statistics, artificial intelligence predictive modeling, and genetic pathway analysis, one can gain further insight into sex-specific gene expression patterns, potentially driving the valvular phenotype differences between the sexes.•Results from this study, implementing a mixed and comprehensive methodological approach, offer a foundation for further exploration of potential drug targets.