Is the mechanism of COVID-19 coagulopathy still a rabbit’s hole?

Ashna Rajan, Ganesh Keshav Thirunavukkarasu,Richard F. Lockey,Narasaiah Kolliputi

Journal of Cell Communication and Signaling（2021）

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摘要

The pathophysiology of COVID-19 is an enigma with its severity often determined by the extent of coagulopathy. Several regulatory pathways targeted by the SARS-CoV-2 include the renin-angiotensin system, von Willebrand Factor, and most importantly, the complement pathway. This article discusses these pathways to help design potential future therapies.

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关键词

COVID-19, Coagulopathy, ACE2, SARS-CoV2, Complement, Thromboinflammation

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