Two-Photon Fluorescence And Mr Bio-Imaging Of Endogenous H2o2 In The Tumor Microenvironment Using A Dual-Mode Nanoprobe

The dual-mode bio-imaging nanoprobe TP-CQDs@MnO2, based on two-photon carbon quantum dots and MnO2, has been developed for the two-photon fluorescence and MR imaging of endogenous H2O2 in the tumor microenvironment, and it achieved high selectivity, a great signal-to-noise ratio, a limit of detection (LOD) of 1.425 pM for H2O2, and a two-photon tissue penetration depth of 280 mu m.