Variant Analyses Of Candidate Genes In Orofacial Clefts In Multi-Ethnic Populations
Mary Li,Joy Olotu, Carmen J Buxo-Martinez,Peter A Mossey,Deepti Anand,Tamara Busch,Azeez Alade,Lord J J Gowans,Mekonen Eshete,Wasiu L Adeyemo,Thirona Naicker,Waheed O Awotoye,Sagar Gupta,Chinyere Adeleke,Valeria Bravo,Siyong Huang,Olatunbosun O Adamson, Ada M Toraño, Carolina A Bello, Mairim Soto, Marilyn Soto, Ricardo Ledesma, Myrellis Marquez,Jose F Cordero,Lydia M Lopez-Del Valle, Maria I Salcedo, Natalio Debs,Aline Petrin,Hannah Malloy,Khalid Elhadi,Olutayo James,Mobolanle O Ogunlewe,Fekir Abate,Abiye Hailu,Ibrahim Mohammed,Paul Gravem,Milliard Deribew,Mulualem Gesses,Mohaned Hassan,John Pape,Solomon Obiri-Yeboah,Fareed K N Arthur,Alexander A Oti,Peter Donkor,Mary L Marazita,Salil A Lachke,Adebowale A Adeyemo,Jeffrey C Murray,Azeez Butali FASEB JOURNAL（2021）
Abstract
This study provides evidence that variants in SHH, RORA, MRPL53, ACVR1, and GDF11 may contribute to risk of orofacial clefts in various populations.
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Key words
Candidate Gene,Congenital Birth Defect,Craniofacial Genetics,Genome-Wide Association Studies,Novel Variants,Whole Exome Sequencing
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