Dietary therapeutic dose of oxytetracycline negatively influences the antioxidant capacity and immune-related genes expression in Nile tilapia Oreochromis niloticus (L.)

Jawahar Abraham Thangapalam,Roy Beryl Julinta,Anwesha Roy,Jasmine Singha,Prasanna Kumar Patil,Kesavan Ashok Kumar,Prasenjit Paria,Bijay Kumar Behera

Environmental Toxicology and Pharmacology（2021）

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摘要

•Effects of dietary oxytetracycline (OTC) in Oreochromis niloticus were evaluated.•Dietary OTC caused insignificant mortalities and growth retardation.•OTC residue levels never exceeded the MRL set by the Codex Alimentarius.•Dietary OTC reduced the antioxidant capacity of the liver and muscle tissues.•TNF-α, IL-1β and HSP70 genes in the fish liver were down-regulated significantly.

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关键词

Oreochromis niloticus,Oxytetracycline-dosing,Oxytetracycline-residues,Antioxidant capacity,Immune-related gene expression

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