UPLC-Q-Exactive-MS analysis for hepatotoxicity components of Evodiae Fructus based on spectrum-toxicity relationship

Wei Zhang,Kun Ren,Shumeng Ren,Shuang Lv,Yingni Pan,Dongmei Wang,Toshio Morikawa,Xiaoqiu Liu

Journal of Chromatography B（2021）

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摘要

•The hepatotoxicity of EF was different among SEF, MEF, BEF.•There were no regions specificity in hepatotoxicity of Evodiae Fructus.•Spectrum-effect relationships between fingerprints and hepatotoxicity of Evodiae Fructus were established.•The hepatoprotection of LIM and hepatotoxicity of EVO were experimentally verified.

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关键词

Evodiae Fructus,Spectrum-toxicity relationship,UPLC-Q-Exactive-MS

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